TRP Channels in Drug Discovery
Volume I
(Sprache: Englisch)
With state-of-the-art reviews of the most interesting TRP channels, from TRPA1 to TRPV4, this volume contains key tips on implementation as well as clear and focused laboratory-ready protocols on TRP channels and disorders of airways and the GU tract.
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With state-of-the-art reviews of the most interesting TRP channels, from TRPA1 to TRPV4, this volume contains key tips on implementation as well as clear and focused laboratory-ready protocols on TRP channels and disorders of airways and the GU tract.
Klappentext zu „TRP Channels in Drug Discovery “
Recent findings have implied a distinct therapeutic potential for drugs targeting Transient Receptor Potential (TRP) channels in a wide variety of diseases, many with no existing satisfactory treatment options. Thus, the TRP superfamily of ion channels has attracted a great deal of well-deserved attention. TRP Channels in Drug Discovery provides a thorough collection of the most up-to-date reviews and protocols on the subject, coming from top experts in the field. Volume I presents a series of state-of-the-art minireviews on the most interesting TRP channels (from TRPA1 to TRPV4), as well as TRP-related protocols involving airways and the genitourinary tract. Written for the Methods in Pharmacology and Toxicology(TM) series, this work includes the kind of detailed description and key implementation advice that ensures successful results in the lab.Comprehensive and cutting-edge, TRP Channels in Drug Discovery serves as an ideal reference for graduate students in academic laboratories as well as for pharmaceutical scientists developing new drugs and clinicians interested in novel drugs in the pipeline.
Inhaltsverzeichnis zu „TRP Channels in Drug Discovery “
Introduction to TRPs: A Quest for Novel Drug Targets.- TRP-Mediated Cytoskeletal Reorganization: Implications for Disease and Drug Development.- TRPA1 in Drug Discovery.- Canonical Transient Receptor Potential Channel (TRPC) Expression, Regulation, and Function in Vascular and Airway Diseases.- TRPM2 Function and Potential as a Drug Target.- The Ca2+-Activated Monovalent Cation Selective Channels TRPM4 and TRPM5.- The Emerging Role of TRPM7 in the Regulation of Magnesium Homeostasis.- TRPM8 Channels as Potential Therapeutic Targets for Pain, Analgesia, and Thermoregulation.- TRPML Channels in Function, Disease, and Prospective Therapies.- The TRPP Signalling Module: TRPP2/Polycystin 1 and TRPP2/PKD1L1.- TRPV1 as a Polymodal Sensor: Potential to Discover TRPV1 Antagonists Selective for Specific Activating Modalities.- Nociceptive and Non-Nociceptive Roles of TRPV3 and Its "Druggability".- TRPV4 and Drug Discovery.- TRP Expression and Function in the Lung Airways.- Hypoxia-Dependent TRP Channel Function in Pulmonary Arterial Smooth Muscle Cells.- Endotoxin-Induced Airway Inflammation and Asthma Models.- Enhanced Cough, Animal Models.- Capsaicin Inhalation Test in Man.- TRP Channels in the Genitourinary (GU) Tract.- Animal Models of Cystitis.- Overactive Bladder Models.
Bibliographische Angaben
- 2016, Softcover reprint of the original 1st ed. 2012, XI, 446 Seiten, Maße: 17,8 x 25,4 cm, Kartoniert (TB), Englisch
- Herausgegeben: Arpad Szallasi, Tamás Bíró
- Verlag: Springer, Berlin
- ISBN-10: 1493962817
- ISBN-13: 9781493962815
Sprache:
Englisch
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