Total Synthesis of Bioactive Natural Products by Palladium-Catalyzed Domino Cyclization of Allenes and Related Compounds
(Sprache: Englisch)
This book details efficient synthetic approaches for biologically active compounds. It describes novel methodologies for highly efficient construction of functionalized heterocycles by palladium-catalyzed domino cyclization of allenes and related compounds.
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This book details efficient synthetic approaches for biologically active compounds. It describes novel methodologies for highly efficient construction of functionalized heterocycles by palladium-catalyzed domino cyclization of allenes and related compounds.
Klappentext zu „Total Synthesis of Bioactive Natural Products by Palladium-Catalyzed Domino Cyclization of Allenes and Related Compounds “
The author has developed novel methodologies for highly efficient construction of functionalized heterocycles by palladium-catalyzed domino/cascade cyclization of allenes and related compounds containing appropriate nucleophilic group(s). Based on these methodologies, enantioselective total syntheses of bioactive natural products, pachastrissamine (26% overall yield in seven steps), lysergic acid (4.0% overall yield in fifteen steps), lysergol (3.6% overall yield in fifteen steps) and isolysergol (8.2% overall yield in eleven steps) have been achieved. These are more facile synthetic route than those previously reported. These findings would contribute to the development of efficient synthetic methods for biologically active compounds containing a complex structure.
Inhaltsverzeichnis zu „Total Synthesis of Bioactive Natural Products by Palladium-Catalyzed Domino Cyclization of Allenes and Related Compounds “
Chapter 1. Total Synthesis of Pachastrissamine (Jaspine B) .- Chapter 2. Total Synthesis of Lysergic Acid, Lysergol, and Isolysergol .- Chapter 3. Conclusions.
Bibliographische Angaben
- Autor: Shinsuke Inuki
- 2016, Softcover reprint of the original 1st ed. 2012, XVI, 106 Seiten, Maße: 15,6 x 23,6 cm, Kartoniert (TB), Englisch
- Verlag: Springer, Berlin
- ISBN-10: 4431561102
- ISBN-13: 9784431561101
Sprache:
Englisch
Pressezitat
From the reviews:"The target audience ... includes practicing organic chemists with interests in synthesis, and those with specific interests in palladium-catalysed organic reactions, and as such is suited to graduate level and above. ... is well-written and provides plenty of food for thought for specialists in palladium(II) chemistry ... . the book also benefits from a comprehensive experimental section at the end of each chapter. ... the book reflects the high quality experimental skills of the author, and provides a useful handbook for the synthetic organometallic chemist." (Edward A. Anderson, Platinum Metals Review, Vol. 56 (3), 2012)
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