Topics in Biomedical Gerontology

1. Identification of serum sirtuins as novel non-invasive protein markers for frailty.- 2.Age-related morphological changes in the human pancreas.- 3.Changing population of neurons and glia in the human cochlear nucleus during aging.- 4.Age-related changes in the expression level of insulin-like growth factor-1 and its related signaling pathway in mice.- 5.Differential expression of arginase I and its regulation by dexamethasone in the liver of mice as a function of age.- 6.Molecular and cellular basis of memory enhancing effects ofBacopa monnieri extract on diabetes mellitus induced memory impairment in mice.- 7.Brain aging and oxidative pathology.- 8.Antiepileptic potential of dehydroepiendrosterone (DHEA).- 9.Curcumin attenuates memory impairment by modulating the expression of CamKII during aging.- 10.Dietary restriction, an intervention for healthy aging.- 11.Study of anti-ageing property of moringaoleifera leaves in fish brain.- 12.Alterations in the structure and functionof the chromatin during aging.- 13.Postnatal exposure of PBDE-209 impairs spatial memory in young mice:Relation of glutamate and oxidant-antioxidant homeostasis in the frontal cortex and hippocampus.- 14.Differential expression of long intergenic noncoding RNA (lincRNA) in the rat brain during aging.- 15.Dietary restriction up-regulates expression and activity of cardiac and skeletal muscle inorganic pyrophosphatase in mice as a function of age.- 16.Age-related changes in rat kidney antioxidant enzymes and oxidative stress parameters with special reference to catalase  promoter methylation pattern.- 17.Recovery of age-related memory loss: hopes and challenges.- 18.Electrophysiological ageing of the brain : Ageing-related impairments in neuronal and cognitive functions.- 19.Role of autophagy in life-extension using Dictyostelium discoideum as a model system.- 20.SIRT-1: An emerging target for age-related neurodegenerative diseases.- 21.Neuroinflammation and the aging brain.- 22.Expression

Pramod C. Rath is a Professor of Molecular Biology and has been Acting Dean of the School of Life Sciences, Jawaharlal Nehru University, New Delhi. He received his Ph. D. in 1988 from the Biochemistry Section of the Zoology Department, Banaras Hindu University, Varanasi, India on "Expression and Modulation of Genes during Aging of the Rat" under the supervision of Prof. M. S. Kanungo. He did his post-doctoral research at the Institute for Molecular Biology I, University of Zurich, ETH-Hoenggerberg from 1989 to 1990 on "Regulation of Interferon Gene Expression in Mammalian Cells" with Prof. Charles Weissmann, Director. He joined the School of Life Sciences, Jawaharlal Nehru University, New Delhi as an Assistant Professor (Molecular Biology) in December 1990. He went to Cold Spring Harbor Laboratory, New York, as a Short-term Scholar in March, 1998 to work on "Advanced Genome Sequencing and Analysis" with Prof. Richard MacCombie, Chief, Genome Sequencing Research Group. He wasa Visiting Research Scientist during 1998-99 at the University of Texas M. D. Anderson Cancer Center, Houston, Texas and worked on "Cytokine Signalling and Cancer" with Prof. Bharat B. Aggarwal, Chief, Cytokine Research Laboratory. He also went to the Stem Cell Institute, Medical School, University of Minnesota, Minneapolis as a Short-term Scholar during Nov.-Dec., 2005 and worked on "Multipotent Adult Progenitor Cells (MAPCs)" with Prof. Catherine Verfaillie, Director. He has 25 years of teaching and research experience, having mentored 17 Ph. D. and 3 M. Phil. students. He teaches Molecular Biology, Molecular Genetics and Cell Signalling courses at M. Sc. and Pre-Ph. D. levels. His research areas include (i) Genomic Biology of Repetitive DNA and Noncoding RNA; (ii) Cytokines, Transcription Factors, Cell Signalling and Disease and (iii) Mesenchymal Stem Cells from Bone Marrow and Regenerative Medicine. He has many research publications to his credit in reputed international journals,such