Targeting the Wnt Pathway in Cancer
(Sprache: Englisch)
Inappropriate activation of the Wnt signaling pathway is observed in many human cancers and is sufficient to drive tumor initiation and progression in numerous contexts. Multiple mechanisms, such as overexpression of Wnt ligands, inactivation of the APC and...
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Inappropriate activation of the Wnt signaling pathway is observed in many human cancers and is sufficient to drive tumor initiation and progression in numerous contexts. Multiple mechanisms, such as overexpression of Wnt ligands, inactivation of the APC and Axin tumor suppressors, and mutation of ?-catenin, are responsible for pathway activation in tumor cells. The development of potent Wnt pathway antagonists for therapeutic use has been a major effort for investigators in both academia and industry in recent years. This book will provide an overview of the Wnt pathway as a therapeutic target for cancer, and discuss the preclinical development of inhibitors specifically directed to upstream and downstream components of the pathway.
Klappentext zu „Targeting the Wnt Pathway in Cancer “
Inappropriate activation of the Wnt signaling pathway is observed in many human cancers and is sufficient to drive tumor initiation and progression in numerous contexts. Multiple mechanisms, such as overexpression of Wnt ligands, inactivation of the APC and Axin tumor suppressors, and mutation of -catenin, are responsible for pathway activation in tumor cells. The development of potent Wnt pathway antagonists for therapeutic use has been a major effort for investigators in both academia and industry in recent years. This book will provide an overview of the Wnt pathway as a therapeutic target for cancer, and discuss the preclinical development of inhibitors specifically directed to upstream and downstream components of the pathway.
Inhaltsverzeichnis zu „Targeting the Wnt Pathway in Cancer “
Chapter 1. An Introduction to Wnt Signaling Paul Polakis
Chapter 2. Regulation of Wnt Secretion and Distribution
Xiaofang Tang Xiaolan Fan and Xinhua Lin
Chapter 3. Wnt Signaling in Stem Cells
Philipp C. Manegold, Jia-Ling and Teo Michael Kahn
Chapter 7. Use of Genetically-engineered Mouse Models in Identification and Validation of Therapeutic Targets for Colon Cancer
Masahiro Aoki and Makoto Mark Taketo
Chapter 8. Targeting Wnt Signalling in Cancer
Aliaksei Holik and Alan R. Clarke
Cardiff School of Biosciences, Cardiff University,Cardiff, UK
Chapter 9. Inhibiting the Wnt Signaling Pathway with Small Molecules
Ho-Jin Lee, Xinxin Zhang, and Jie J. Zheng
Chapter 10. Targeting of Wnt Signaling Inside the Nucleus
Miki Shitashige and Tesshi Yamada
Markus Müschen
Chapter 7. Use of Genetically-engineered Mouse Models in Identification and Validation of Therapeutic Targets for Colon Cancer
Masahiro Aoki and Makoto Mark Taketo
Chapter 8. Targeting Wnt Signalling in Cancer
Aliaksei Holik and Alan R. Clarke
Cardiff School of Biosciences, Cardiff University,Cardiff, UK
Chapter 9. Inhibiting the Wnt Signaling Pathway with Small Molecules
Ho-Jin Lee, Xinxin Zhang, and Jie J. Zheng
Chapter 10. Targeting of Wnt Signaling Inside the Nucleus
Miki Shitashige and Tesshi Yamada
Chapter 4. Crosstalk of the Wnt Signaling Pathway
Michael Thompson, Kari Nejak-Bowen, Satdarshan P. S. Monga
... mehr
Chapter 5. Dysregulation of the WNT Pathway in Solid Tumors
Jenifer R. Prosperi, Hue H. Luu and Kathleen H. Goss
Chapter 6. WNT/b-catenin Signaling in Leukemia
Markus Müschen
Chapter 7. Use of Genetically-engineered Mouse Models in Identification and Validation of Therapeutic Targets for Colon Cancer
Masahiro Aoki and Makoto Mark Taketo
Chapter 8. Targeting Wnt Signalling in Cancer
Aliaksei Holik and Alan R. Clarke
Cardiff School of Biosciences, Cardiff University,Cardiff, UK
Chapter 9. Inhibiting the Wnt Signaling Pathway with Small Molecules
Ho-Jin Lee, Xinxin Zhang, and Jie J. Zheng
Chapter 10. Targeting of Wnt Signaling Inside the Nucleus
Miki Shitashige and Tesshi Yamada
Jenifer R. Prosperi, Hue H. Luu and Kathleen H. Goss
Chapter 6. WNT/b-catenin Signaling in Leukemia
Markus Müschen
Chapter 7. Use of Genetically-engineered Mouse Models in Identification and Validation of Therapeutic Targets for Colon Cancer
Masahiro Aoki and Makoto Mark Taketo
Chapter 8. Targeting Wnt Signalling in Cancer
Aliaksei Holik and Alan R. Clarke
Cardiff School of Biosciences, Cardiff University,Cardiff, UK
Chapter 9. Inhibiting the Wnt Signaling Pathway with Small Molecules
Ho-Jin Lee, Xinxin Zhang, and Jie J. Zheng
Chapter 10. Targeting of Wnt Signaling Inside the Nucleus
Miki Shitashige and Tesshi Yamada
... weniger
Bibliographische Angaben
- 2011, XI, 240 Seiten, Maße: 16 x 24,1 cm, Gebunden, Englisch
- Herausgegeben: Kathleen H. Goss, Michael Kahn
- Verlag: Springer, Berlin
- ISBN-10: 1441980229
- ISBN-13: 9781441980229
- Erscheinungsdatum: 28.01.2011
Sprache:
Englisch
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