Redox-Active Therapeutics

Part1. Pathophysiological Roles of Superoxide Dismutases (SOD).- Superoxide and theSuperoxide Dismutases: An Introduction by Irwin Fridovich.- The Discovery ofSuperoxide Dismutase and Its Role in Redox Biology.- Manganese SuperoxideDismutase (MnSOD) and It's Importance in Mitochondrial Function and Cancer.- Regulationof the Cellular Redox Environment by Superoxide Dismutases, Catalase and GlutathionePeroxidases During Tumor Metastasis.- Superoxide Dismutase Family of Enzymes inBrain Neurogenesis and Radioprotection.- Metabolic Production of H2O2in Carcinogenesis and Cancer Treatment.- Part 2. Redox-Active Therapeutics -Design and Mechanisms of Action.- Mimicking SOD, Why and How: Bio-InspiredManganese Complexes as SOD Mimics.- Mn Porphyrin-Based Redox-ActiveTherapeutics.- Cytochrome P450-like Biomimetic Oxidation Catalysts Based on Mnporphyrins as Redox Modulators.- Nitrones as Potent Anticancer Therapeutics.- SalenManganese Complexes Mitigate Radiation Injury in Normal Tissues ThroughModulation of Tissue Environment.- Molecular Basis for Anticancer and AntiparasiteActivities of Copper-Based Drugs.- Small Signaling Molecules and CO-ReleasingMolecules (CORMs) for the Modulation of the Cellular Redox Metabolism.- HNO/ThiolBiology as a Therapeutic Target.- Part 3. Redox-Active Therapeutics in Cancer.-Advances in Breast Cancer Therapy Using Nitric Oxide and Nitroxyl Donor Agents.-Mechanisms by Which Manganese Porphyrins Affect Signaling in Cancer Cells.- TargetedTherapy for Malignant Brain Tumors.- Redox Therapeutics in Breast Cancer: Role ofSOD Mimics.- Anticancer Action of Mn porphyrins in Head and Neck Cancers.- Redox-basedTherapeutic Strategies in the Treatment of Skin Cancers.- Role of Oxidative Stressin Erectile Dysfunction after Prostate Cancer Therapy.- Theranostic Nanoconjugatesof Tetrapyrrolic Macrocycles and Their Applications in Photodynamic Therapy.-Part 4. Redox-Active Therapeutics in Other Diseases.- QuantumDots inPhotodynamic Therapy.- Metalloporphyrins

INES BATINIC-HABERLE,PhD

Ines Batinic-Haberle is a Professor of RadiationOncology at the Department of Radiation Oncology, Duke University School ofMedicine. She received her B.Sc. in Food Chemistry, M.Sc. degree in AnalyticalChemistry, and her Ph.D. degree in Bioinorganic Chemistry from the School ofPharmacy and Biochemistry, University of Zagreb, Croatia. She completed herpostdoctoral education at the Department of Chemistry, Duke University. She thenmoved to the Department of Biochemistry at Duke University School of Medicine,where she was trained by Irwin Fridovich, the Father of the field of Free Radicals in Biology and Medicine. Shespent 10 years in Fridovich's Lab where she acquired the basis of her expertisein Oxidative Stress and Redox-Active Therapeutics and launchedthe design of powerful Mn porphyrin-based SOD mimics.  She established the structure-activityrelationship for Mn porphyrin-based SOD mimics, which she subsequently extendedto all classes of SOD mimics. She holds a number of compositional and methodsof use patents on metalloporphyrins; her lead compounds are either already inor entering Clinical Trials in 2016. She authored more than 190 manuscripts,several book chapters, has served as Guest/Invited Editor and reviewer ofvarious prestigious journals and granting agencies both nationally and internationally.For the last 6 years she has served as a Societyfor Redox Biology and Medicine (SFRBM) Officer and is a founding member ofthe Society of Porphyrins andPhthalocyanines. She was recently awarded the SFRBM Excellence in MentoringAward. She has organized numerous Symposia nationally and internationally andgave lectures at numerous Universities in the USA and abroad. She hasestablished numerous collaborations with research groups in USA andinternationally and worked actively in advancing metalloporphyrins towardsclinic.

JULIO S. REBOUCAS, PhD