Protein Degradation.Vol.3

Deubiquitylating enzymes

Ubiquitin and tyrosine kinase receptors

The COP9/signalosome complex

Regulation of the NFKB system by ubiquitin

Ubiquitin in transcription

Ubiquitin in DNA monitoring and repair

Ubiquitin in peroxisomes

Ubiquitin and endocytosis

Ubiquitin and membrane trafficking

The ubiquitin-proteasome system and muscle development

Ubiquitin and the cell cycle

The ubiquitin-proteasome system in plants

(partial contents)

John Mayer obtained his MS and PhD degrees from the University of Birmingham (UK). He is currently serving as Professor of Biochemistry at the School of Biomedical Sciences at Nottingham University.

For the past 30 years, he has investigated intracellular proteolysis and particularly the ubiquitin/proteasome system. Presently, he is particularly interested in intracellular proteolysis in relation to neurodegenerative illnesses.

Aaron Ciechanover obtained his MD from the Hebrew University in Jerusalem (Israel), and his PhD from the Technion-Israel Institute of Technology in Haifa, where he is presently serving as Professor of Biochemistry. Professor Ciechanover is known for his discovery of the first ubiquitin system mutant cell, demonstrating the role of the ubiquitin-proteasome proteolytic system in protein degradation in vivo. In 2004, he has received the Nobel Prize in Chemistry for his ground-breaking work on the ubiquitin-proteasome system.

Martin Rechsteiner is Professor of Biochemistry at the University of Utah in Salt Lake City (USA). He is interested in the proteasome component of the ubiquitin-proteasome pathway. He has identified several key regulators of proteasome function and is currently working on their structural and functional elucidation.