Peptide Macrocycles

Three Methods for Peptide Cyclization via Lactamization.- Solid-Phase Peptide Cyclization with Two Disulfide Bridges.- Peptide Macrocyclization through Palladium-Catalyzed Late-Stage C-H Activation.- Three Methods for the Solution Phase Synthesis of Cyclic Peptides.- Computational Design of Structured and Functional Peptide Macrocycles.- On-Resin Peptide Cyclization Using the 3-4-Amino-(Methylamino)Benzoic Acid (MeDbz) Linker.- Scalable and Efficient in planta Biosynthesis of Sunflower Trypsin Inhibitor-1 (SFTI) Peptide Therapeutics.- Ligation, Macrocyclization, and Simultaneous Functionalization of Peptides by Multicomponent Reactions (MCR).- Diels-Alder Cycloadditions for Peptide Macrocycle Formation.- Protein Catalyzed Capture (PCC) Agents for Antigen Targeting.- Preparation of Bacterial Cell-Surface Displayed Semisynthetic Cyclic Peptides.- The Discovery of Peptide Macrocycle Rescuers of Pathogenic Protein Misfolding and Aggregation by Integrating SICLOPPS Technology and Ultra-Throughput Screening in Bacteria.- In Vitro Selection of Thioether-Closed Macrocycle Peptide Ligands by Means of the RaPID System.- MOrPH-PhD: A Phage Display System for the Functional Selection of Genetically Encoded Macrocyclic Peptides.- Discovery of Antimicrobial Peptide Macrocycles Through Bacterial Display.- Assessing the Cellular Uptake, Endosomal Escape, and Cytosolic Entry Efficiencies of Cyclic Peptides.- In silico Analysis of Peptide Macrocycle-Protein Interactions.- Binding Characterization of Cyclic Peptide Ligands to Target Proteins and Chemical Epitopes using ELISA and Fluorescence Polarization Assays.- Determining the Binding Kinetics of Peptide Macrocycles using Bio-Layer Interferometry (BLI).- Different Approaches to Cyclize a Cell-Penetrating Peptide and to Tether Bioactive Payloads.- Helical Stabilization of Peptide Macrocycles by Stapled Architectures.- Development