Microbial DNA and Host Immunity

Part I. Introduction

Immunostimulatory DNA: An Overview

Eyal Raz

Historical Perspectives

Saburo Yamamoto, Toshiko Yamamoto, and Tohru Tokunaga

Part II. Receptors and Signaling

Signal Transduction Pathways Activated by CpG-DNA

Hans Häcker

A Novel Toll-Like Receptor that Recognizes Bacterial DNA

Hiroaki Hemmi and Shizuo Akira

Activation of Innate Immunity by Microbial Nucleic Acids

Wen-Ming Chu, Xing Gong, and Tony Yoon

Phosphorothioate Backbone Modification Changes the Pattern of Responses to CpG

Katryn J. Stacey, David P. Sester, Shalin Naik, Tara L. Roberts, Matthew J. Sweet, and David A. Hume

Part III. Cell Activation

Activation of NK Cell by Immunostimulatory Oligo-DNA in Mouse and Human

Saburo Yamamoto, Toshiko Yamamoto, Tetsuro Kataoka, Sumiko Iho, and Tohru Tokunaga

Regulation of Antigen Presenting Cell Function by CpG-DNA

David Askew, Rose S. Chu, and Clifford V. Harding

Activation of B Cells by CpG Motifs in Bacterial DNA, Ae-Kyung Yi and Arthur M. Krieg

IFN-Dependent Pathways for Stimulation of Memory CD8+ Cells

Jonathan Sprent

Cross Priming of CD8+ T Cells by Immunostimulatory Sequence DNA

Hearn Jay Cho, Sandip Datta, and Eyal Raz

Part IV. Vaccination Strategies

The Th1 Adjuvant Effect of Immunostimulatory DNA Sequences

Maripat Corr and Chih Min Tang

Immunostimulatory DNA Pre-Priming for the Induction of Th1 and Prevention of Th2 Biased Immune Responses

Hiroko Kobayashi, Elena Martin-Orozco, Kenji Takabayashi, and Anthony A. Horner

Protein-Immunostimulatory DNA-Conjugate: A Novel Immunogen

Kenji Takabayashi, Helen Tighe, Lucinda Beck, and Hans L. Spiegelberg

Immunostimulatory DNA Sequence-Based Mucosal Vaccines

Anthony A. Horner

Enhancement of the Immunoadjuvant Activity of Immunostimulatory DNA Sequence by Liposomal Delivery

Eli Kedar, Igal Louria-Hayon, Aviva Joseph, Zichria Zakay-Rones, Tomoko Hayashi, Kenji Takabayashi, and Yechezkel

"I am delighted, therefore to have found this book, which thoroughly reviews the field by contributions from most of the key names associated with the subject. For those not yet initiated into the tell-tale nature of ISS-DNA presented by non-self, the excellent introductory chapter by Eyal Raz(Editor) will reveal all you need to know to read the rest of the book. It summarizes the role of Toll Receptors(TLR) as sensors of infection by recognition of conserved molecular patterns in pathogenic bacteria (PAMPS), a subject very topical these days but riddled with a lot of new reference terms for the poor immunologist to contend with. This new book highlights the fact that even the ubiquitous DNA molecule has been the subject of critical censorship during evolution and has allowed the mammalian innate immune response to use subtle differences between prokaryotic and eukaryotic DNA to inform of bacterial invasion...recommended as an excellent library acquisition, if not a departmental one." -- Immunology News

"This is a worthwhile endeavor and the book is of value. Investigators interested in the overall utility of these DNA sequences will find useful material..." -Doody's Health Sciences Book Review Journal

"I am delighted, therefore to have found this book, which thoroughly reviews the field by contributions from most of the key names associated with the subject. For those not yet initiated into the tell-tale nature of ISS-DNA presented by non-self, the excellent introductory chapter by Eyal Raz(Editor) will reveal all you need to know to read the rest of the book. It summarizes the role of Toll Receptors(TLR) as sensors of infection by recognition of conserved molecular patterns in pathogenic bacteria (PAMPS), a subject very topical these days but riddled with a lot of new reference terms for the poor immunologist to contend with. This new book highlights the fact that even the ubiquitous DNA molecule has been the subject of critical censorship during evolution and has allowed the mammalian innate immune response to use subtle differences between prokaryotic and eukaryotic DNA to inform of bacterial invasion...recommended as an excellent library acquisition, if not a departmental one." -- Immunology News

"This is a worthwhile endeavor and the book is of value. Investigators interested in the overall utility of these DNA sequences will find useful material..." -Doody's Health Sciences Book Review Journal