Heteroaromatic Lipoxin A4 Analogues
Synthesis and Biological Evaluation
(Sprache: Englisch)
This review of the chemistry and biology of stable lipoxin analogues describes for the first time the synthesis of an enantiomerically pure form of pyridine-containing LXA4, as well as a route to synthesizing a thiophene-containing LXA4 analogue.
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This review of the chemistry and biology of stable lipoxin analogues describes for the first time the synthesis of an enantiomerically pure form of pyridine-containing LXA4, as well as a route to synthesizing a thiophene-containing LXA4 analogue.
Klappentext zu „Heteroaromatic Lipoxin A4 Analogues “
In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed interesting biological activity. Both routes have inspired further work in the synthesis of further heteroaromatic analogues for biological evaluation.
Inhaltsverzeichnis zu „Heteroaromatic Lipoxin A4 Analogues “
Introduction.- Recent advances in the chemistry and biology of stable synthetic Lipoxin analogues.- Synthesis of Heck coupling partner for the preparation of heteroaromatic Lipoxin A4 analogues.- Synthesis and biological evaluation of pyridine-containing Lipoxin A4 analogues.- Thiophene-containing Lipoxin A4 analogues: synthesis and their effect on the production of key cytokines.- Towards the synthesis of various heteroaromatic Lipoxin A4 analogues.
Bibliographische Angaben
- Autor: Colm Duffy
- 2014, 2012, XXII, 130 Seiten, Maße: 15,5 x 23,5 cm, Kartoniert (TB), Englisch
- Verlag: Springer, Berlin
- ISBN-10: 364243892X
- ISBN-13: 9783642438929
Sprache:
Englisch
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