Handbook of Drug Monitoring Methods

to Therapeutic Drug Monitoring.- Monitoring Free Drug Concentration.- Analytical Techniques for Measuring Concentrations of Therapeutic Drugs in Biological Fluids.- The Pre-Analytical Phase of Drug Testing.- Effect of Hemolysis, High Bilirubin, Lipemia, Paraproteins, and System Factors on Therapeutic Drug Monitoring.- Digoxin.- Interferences with Measurement of Anticonvulsants.- Pitfalls in Measuring Antidepressant Drugs.- Immunosuppressive Drugs.- Therapeutic Drug Monitoring in Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome.- Pharmacogenomics and Personalized Medicine.- Interference of Heterophilic and Other Antibodies in Measurement of Therapeutic Drugs by Immunoassays.- Drug-Herb and Drug-Food Interactions.- Toxic Element Testing with Clinical Specimens.- Alcohol Testing.- to Drugs of Abuse Testing.- Urinary Adulterants and Drugs of Abuse Testing.- Hair, Oral Fluid, Sweat, and Meconium Testing for Drugs of Abuse.- Abused and Designer Drugs and How They Escape Detection.- Interpretation of Amphetamines Screening and Confirmation Testing.- Clinical False-Positive Drug Test Results.- Providing Expert Witness for Alcohol and Positive Drugs of Abuse Test Results.

In this handbook, the authors discuss the different analytical techniques used in today s practice of therapeutic drug monitoring and drugs of abuse as well as alcohol testing. The volume s first half focuses on various issues of therapeutic drug monitoring. Additional chapters cover analysis of heavy metals, alcohol testing, and issues of drugs of abuse testing. These chapters are written by experts in their relative sub-specialties and also by the editor.
This volume is the perfect handbook and quick reference for any clinical laboratory, allowing clinicians to find the potential source of a false-positive or a false-negative result in the daily operation of a toxicology laboratory. At the same time, this book can also be used as a reference for medical technologists, supervisors, laboratory directors, clinical chemists, toxicologists, and pathologists to find in-depth cause of a potential interference and what tests can be ordered to circumvent such problem.

From the reviews:"This is a comprehensive handbook on all aspects of drug monitoring. ... This has broad appeal. Of course it would appeal to anyone actively measuring drug levels (i.e., clinical laboratory scientists, toxicologists, clinical chemists). It would also appeal to anyone interested in how such testing is performed and the pitfalls in interpreting results (students or practitioners in any medical discipline or allied health field, poison control centers, concerned parents, etc.). ... This is a very nice addition to the field of drug testing and monitoring." (Valerie L., Doody's Review Service, February, 2008)"This book addresses the issues of therapeutic drug monitoring but also includes information about drugs of abuse, natural products and toxic elements. ... The volume is an ideal reference for clinical laboratories ... . A sturdy construction, good quality paper, a pleasant layout, the inclusion of graphs and diagrams, as well as chemical structures, copious relevant references and a detailed index make this an extremely useful book. If this is your field then this book should be with you." (Steve Mitchell, International Society for the Study of Xenobiotics Newsletter, Spring, 2008)"A comprehensive textbook covering the theory and practice of drug analysis as well as the reasons behind the methods, their advantages, pitfalls and even what one does with the measurements after they have been acquired. ... To find a text that not only covers all aspects but flows so well across the disciplines is a real rarity. ... It really is unusual to see theory and practice sitting together so comfortably. Overall a refreshing change to books with similar titles ... ." (Graham Lappin, British Toxicology Society Newsletter, Summer, 2008)"This book is meant to be 'a handbook at the bench of a clinical laboratory' to serve as a quick reference to find the source of a false positive or a false negative result. ... also be useful for various other laboratory personnel

From the reviews:



"This is a comprehensive handbook on all aspects of drug monitoring. ... This has broad appeal. Of course it would appeal to anyone actively measuring drug levels (i.e., clinical laboratory scientists, toxicologists, clinical chemists). It would also appeal to anyone interested in how such testing is performed and the pitfalls in interpreting results (students or practitioners in any medical discipline or allied health field, poison control centers, concerned parents, etc.). ... This is a very nice addition to the field of drug testing and monitoring." (Valerie L., Doody's Review Service, February, 2008)

"This book addresses the issues of therapeutic drug monitoring but also includes information about drugs of abuse, natural products and toxic elements. ... The volume is an ideal reference for clinical laboratories ... . A sturdy construction, good quality paper, a pleasant layout, the inclusion of graphs and diagrams, as well as chemical structures, copious relevant references and a detailed index make this an extremely useful book. If this is your field then this book should be with you." (Steve Mitchell, International Society for the Study of Xenobiotics Newsletter, Spring, 2008)

"A comprehensive textbook covering the theory and practice of drug analysis as well as the reasons behind the methods, their advantages, pitfalls and even what one does with the measurements after they have been acquired. ... To find a text that not only covers all aspects but flows so well across the disciplines is a real rarity. ... It really is unusual to see theory and practice sitting together so comfortably. Overall a refreshing change to books with similar titles ... ." (Graham Lappin, British Toxicology Society Newsletter, Summer, 2008)

"This book is meant to be 'a handbook at the bench of a clinical laboratory' to serve as a quick reference to find the source of a false positive or a false negative result. ...