Fragment-based Approaches in Drug Discovery
(Sprache: Englisch)
Discover the modular approach to ligand design! Latest technologies and strategies for fragment-based approaches in the screening and design of pharmaceutically active compounds are discussed here, including numerous case studies.
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Produktinformationen zu „Fragment-based Approaches in Drug Discovery “
Discover the modular approach to ligand design! Latest technologies and strategies for fragment-based approaches in the screening and design of pharmaceutically active compounds are discussed here, including numerous case studies.
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.
Klappentext zu „Fragment-based Approaches in Drug Discovery “
Based on recent successes in the modular design of pharmaceutically active ligands, the concept and technology of fragment-based design has quickly pervaded the research departments of pharma companies, large and small. Drug developers everywhere are currently struggling to keep ahead of the competition by applying these methods to speed up the drug discovery.This first systematic summary of the impact of such approaches on the drug development process provides essential information that was previously unavailable. Adopting a practice-oriented approach, this book by professionals for professionals is indispensable for drug developers in the pharma and biotech sector who need to keep abreast of the latest technologies and strategies in pharmaceutical ligand design. Clearly divided into sections on ligand design, spectroscopic techniques, and screening and drug discovery, the text is backed by numerous case studies.
Inhaltsverzeichnis zu „Fragment-based Approaches in Drug Discovery “
LIGAND DESIGNThe concept of fragment-based ligand design
Additivity and multivalency
Entropic consequences of linking ligands
Protein binding site mapping
Library design for fragment screening
Structural fragments from marketed drugs
Fragment docking to proteins
SPECTROSCOPIC TECHNIQUES
SAR by NMR
NMR for fragment-based ligand design
Fragment-based design by X-ray crystallography
Combined use of NMR and X-ray crystallography
SAR by MS
SCREENING AND DRUG DISCOVERY
Tethering
Click chemistry
Dynamic combinatorial libraries
Autoren-Porträt
Wolfgang Jahnke studied Chemistry at the University of Tübingen (Germany) and obtained a Ph.D. degree from the University of München with Horst Kessler in 1994.He then joined the pharmaceutical industry and is currently head of a drug discovery group at Novartis Pharma AG in Basel (Switzerland). His main expertise is on the application of NMR spectroscopy for drug discovery. In recent years, this has included the development of novel methods for fragment-based ligand design and the characterization of protein-ligand interactions.
Bibliographische Angaben
- 2006, XXII, 369 Seiten, 48 farbige Abbildungen, 88 Schwarz-Weiß-Abbildungen, Maße: 17,5 x 25,1 cm, Gebunden, Englisch
- Herausgegeben: Wolfgang Jahnke, Daniel A. Erlansson, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
- Verlag: Wiley-VCH
- ISBN-10: 3527312919
- ISBN-13: 9783527312917
- Erscheinungsdatum: 20.07.2006
Sprache:
Englisch
Rezension zu „Fragment-based Approaches in Drug Discovery “
'...this is indispensable reading for drug discovery researchers in the pharma and biotech sector.' (Anticancer Research, 2007)
Pressezitat
'...this is indispensable reading for drug discovery researchers in the pharma and biotech sector.' ( Anticancer Research , 2007)
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