Endogenous Toxins, 2 Vols.

PART A: ENDOGENOUS TOXINS ASSOCIATED WITH EXCESSIVE SUGAR, FAT, RED MEAT OR ALCOHOL CONSUMPTION1: Endogenous DNA damage2: Modification of cysteine residues in protein3: Endogenous macromolecule radicals4: Alcohol-derived bioadducts5: Iron from meat produces endogenous pro-carcinogen peroxides6: Short chain sugars as endogenous toxins7: Fructose-derived endogenous toxins8: Cytotoxicity and oxidative stress induced by the glyceraldehyde-related Maillard reaction products9: Estrogens as Endogenous Toxins10: Reactive oxygen species (ROS), hypohalites (HOCI), and reactive nitrogen species (NOS)PART B: GENETICS, ENDOGENOUS TOXINS ASSOCIATED WITH INBORN ERRORS OF METABOLISM11: Oxalate and primary hyperoxaluria12: Pathophysiology of endogenous toxins and their relation to in-born errors of metabolism and drug mediated toxicities13: Mechanisms of toxicity in fatty acid oxidation disorders14: Homocysteine as an endogenous toxin in cardiovascular disease15: Uric acid alterations in cardiometabolic disorders and gout16: Genetic defects in iron and copper trafficking17: Polyglutamine neuropathies: Animal models to molecular mechanismsPART C: EXAMPLES OF ENDOGENOUS TOXINS ASSOCIATED WITH ACQUIRED DISEASES OR ANIMAL DISEASE MODELS18: Alcohol-induced hepatic injury19: Ethanol-induced endotoxemia and tissue injury20: Gut microbiota, diet, endotoxemia and disease21: Nutrient derived endogenous toxins in the pathogenesis of Type 2 diabetes at the beta cell level22: Endogenous toxins and susceptibility or resistance to diabetes complications23: Serum advanced glycation end products associated with NASH and other liver diseases24: Oxidative stress in the pathogenesis of hepatitis C25: Oxidised low density lipoprotein cytotoxicity and vascular disease26: Oxidative stress in breast cancer carcinogenesis27: Lifestyle, endogenous toxins and colorectal cancer risk28: Dopamine-derived neurotoxins and Parkinson's disease29: Dopamine catabolism and Parkinson's disease: Role of a reactive

Peter J. O'Brien is Professor emeritus at the Department of Pharmaceutical Sciences at the University of Toronto (Canada). He obtained his academic degrees from Birmingham University (UK) and took up his first independent scientific position at the Memorial University of Newfoundland in 1967. Since 1986 he has been a full Professor at Toronto. He has more than 300 publication to his name, and was awarded the prestigious McNeil-Janssen-Ortho award for his research in 1996.

William R. Bruce is Professor emeritus at the Departments of Medical Biophysics and Nutritional Sciences at the University of Toronto (Canada). He is a fellow of the Royal Society of Canada and a former director of the American Association for Cancer Research. In 1997 he received the H. O. Warwick Prize of the National Cancer Institute of Canada for his contributions to cancer prevention.