Cell Membranes

1 Regulation of Development by the Extracellular Matrix.- 1. Introduction.- 2. Molecular Analysis, Localization, and Functions of Cell-to-SubstrateAdhesion Molecules.- 3. Involvement of Cell-Substratum Adhesion Molecules in EmbryonicCell Migration.- 4. Involvement of Cell-Substratum Adhesion Molecules in Tissue Remodeling.- 5. Concluding Remarks.- References.- 2 Thrombospondin: A Multifunctional Platelet and Extracellular Matrix Glycoprotein.- 1. Introduction.- 2. Structure and Molecular Interactions of Thrombospondin.- 3. Roles for Thrombospondin in Platelet Function.- 4. Presence of Thrombospondin in Extracellular Matrices.- 5. Possible Functional Roles for Thrombospondin in the ExtracellularMatrix.- 6. Synopsis.- References.- 3 Neuronal Antigens Involved in Cell Adhesion and Cell Recognition.- 1. Introduction.- 2. Identification of Neural Antigens Using Immunological Approaches.- 3. Role of Identified Antigens in Neuronal Cell Recognition.- 4. Neuronal Cell-Adhesion Molecules.- 5. N-CAM.- 6. Relationship of N-CAM to Other Neuronal Cell-Adhesion Molecules.- 7. Conclusions.- References.- 4 Mechanisms of ?1-Adrenergic and Related Responses: Roles ofCalcium, Phospoinositides, Guanine Nucleotides, Diacylglycerol,Calmodulin, and Changes in Protein Phosphorylation.- 1. Introduction.- 2. The ?1Adrenergic Receptor.- 3. Changes in Cell Ca2+ Induced by ?1Adrenergic Agonists.- 4. Role of Phosphoinositide Changes.- 5. Role of Guanine Nucleotide-Binding Regulatory Protein.- 6. Role of Myoinositol Trisphosphate and Ca2+ Release.- 7. Role of Diacylglycerol and Protein Kinase C.- 8. Role of Ca2+ -Calmodulin-Regulated Enzymes and Other Proteins.- 9. Summary.- References.- 5 Regulation of Protein Kinase C by Lipid Cofactors.- 1. Introduction.- 2. Activation of Protein Kinase Cin Vivo by Diacylglycerols.- 3. Activation of Protein Kinase C in Vitro.- 4. Conclusions.- References.- 6 Protein Kinase C and Its Role in Cell Growth.- 1. Introduction.- 2. Protein Kinase C.- 3.