BioNMR in Drug Research
(Sprache: Englisch)
Thanks to the vast progress made in the investigation of biomolecules using NMR over the last few years, NMR spectroscopy offers a universal tool for examining the binding of an active substance to its target protein. Its use also benefits the development of drugs in particular.
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Thanks to the vast progress made in the investigation of biomolecules using NMR over the last few years, NMR spectroscopy offers a universal tool for examining the binding of an active substance to its target protein. Its use also benefits the development of drugs in particular.
Klappentext zu „BioNMR in Drug Research “
The vast progress made in the investigation of biomolecules using NMR has only recently been rewarded with the Nobel Prize for Kurt Wüthrich. Edited by a former coworker of Wüthrich, this book presents the theoretical background on NMR of biomolecules, plus the use of NMR techniques in determining the structures of proteins and nucleic acids.BioNMR spectroscopy offers a universal tool for examining the binding of an active substance to its target protein. Its use thereby benefits the rational development of drugs. This interaction can now be investigated in a hitherto unparalleled precision and displayed in 3D - an important prerequisite for the targeted development of new active substances. The latest methods for characterizing substance-receptor complexes are demonstrated backed by many case studies from pharmaceutical research. Thus it comes as no surprise that a large number of the authors are working for leading pharmaceutical companies.With its successful mixture of basic information and application strategies, coupled with many real-life examples, this is an invaluable guide for both NMR spectroscopists and pharmaceutical researchers.
Inhaltsverzeichnis zu „BioNMR in Drug Research “
BASIC TECHNIQUESModern Methods for Expression of Proteins in Isotopically Enriched FormStructure Calculation Using Automated TechniquesAchieving Better Sensitivity, Less Noise and Less Artifacts in NMR SpectraNMR OF BIOMOLECULESNMR Strategies for Protein AssignmentNMR of Membrane-Associated Peptides and ProteinsNMR of Nucleic AcidsMODERN SPECTROSCOPIC TECHNIQUESMethods for the Measurement of Angle Restraints from Scalar and Dipolar Couplings as well as from Cross Correlated Relaxation: Application to BiomoleculesOrientational RestraintsScalar Coupling Across Hydrogen BondsTROSY:Transverse Relaxation-Optimized SpectroscopyMAS Solid-State NMR of Isotopically Enriched Biological SamplesDetermination of Protein Dynamics Using 15N Relaxation MeasurementsTOOLS FOR INVESTIGATION OF DRUG-RECEPTOR COMPLEXES AND FOR LIGAND SCREENINGThe Determination of Equilibrium Dissociation Constants of Protein-Ligand Complexes by NMRExperiments in NMR-based ScreeningThe Use of Spin-Labels in NMR-supported Lead Finding and OptimizationNMR of Weakly Binding LigandsIsotope Filter and Editing TechniquesSTRATEGIES FOR DRUG DEVELOPMENT USING NMRStrategies for NMR Screening and Library DesignStrategies for Hit Finding Using NMRStrategies for Drug Discovery Using NMRNMR-based Drug Design: Approaches for Very Large Proteins
Bibliographische Angaben
- 2002, 1. Auflage, XVIII, 484 Seiten, 9 farbige Abbildungen, 188 Schwarz-Weiß-Abbildungen, Maße: 17,9 x 24,7 cm, Gebunden, Englisch
- Herausgegeben: Oliver Zerbe, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
- Verlag: Wiley-VCH
- ISBN-10: 3527304657
- ISBN-13: 9783527304653
- Erscheinungsdatum: 27.11.2002
Sprache:
Englisch
Rezension zu „BioNMR in Drug Research “
"The editor has managed to recruit a team of well-recognized experts as authors for this book, thereby ensuring a high standard of reliable and objective reporting. The book is not only of interest to specialists in pharmaceutical research and development, but will certainly also be a valuable resource for everyone concerned with the latest methods of NMR spectroscopy and their application to biomolecules" -- (Angewandte Chemie Int. Ed.)"The book presents a good overview of state-of-the-art NMR techniques in drug discovery. [...] It is suggested reading for people involved in pharmaceutical research as well as academic researchers with an interest in drug discovery." -- (ChemBioChem)
"...certainly a valuable resource for everyone concerned with the latest methods of NMR spectroscopy and their applications..." -- Angewandte Chemie Int. Edition
Pressezitat
"The editor has managed to recruit a team of well-recognized experts as authors for this book, thereby ensuring a high standard of reliable and objective reporting. The book is not only of interest to specialists in pharmaceutical research and development, but will certainly also be a valuable resource for everyone concerned with the latest methods of NMR spectroscopy and their application to biomolecules" (Angewandte Chemie Int. Ed.) "The book presents a good overview of state-of-the-art NMR techniques in drug discovery. [...] It is suggested reading for people involved in pharmaceutical research as well as academic researchers with an interest in drug discovery." (ChemBioChem) "...certainly a valuable resource for everyone concerned with the latest methods of NMR spectroscopy and their applications..." Angewandte Chemie Int. Edition
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