Aspartic Acid Proteases as Therapeutic Targets

OVERVIEW OF ASPARTIC ACID PROTEASESIntroduction to the Aspartic Proteases FamilyAspartic Acid Proteases, Structure, Function and InhibitionHuman Aspartic ProteinasesStructure-based Drug Design Strategies for the Inhibition of Aspartic Acid ProteasesHIV-1 PROTEASE FOR THE TREATMENT OF HIV/AIDSHIV-1 Protease: Role in Viral Replication, Protein-Ligand X-ray Crystal Structures and Inhibitor DesignFirst generation FDA Approved HIV protease inhibitorsSecond-Generation Approved HIV Protease Inhibitors for Treatment of HIV/AIDSDesign, Conception and Clinical Development of Darunavir, a HIV-1 Protease Inhibitor to Combat Drug ResistanceDevelopment of Protease Inhibitors and Challenges to Drug-Resistance of HIV-1RENIN FOR TREATMENT OF HYPERTENSIONDiscovery and Development of Aliskiren, the First-in-Class Direct Renin Inhibitor for the Treatment of HypertensionEvolution of Diverse Classes of Renin Inhibitors Through the YearsGAMMA-SECRETASE FOR TREATMENT OF ALZHEIMER'S DISEASEChemistry and Biology of gamma-Secretase as a Possible Target for Alzheimer's DiseaseGamma-Secretase Inhibition: An overview of Development of Inhibitors for Alzheimer's DiseaseBETA-SECRETASE FOR TREATMENT OF ALZHEIMER'S DISEASEBACE - An (Almost) Perfect Target for Staving Off Alzheimer's DiseaseDiscovery of Memapsin 2 (BACE1), Design of Inhibitors and Drug-design ToolsPeptidomimetic BACE1 Inhibitors for Treatment of Alzheimer's Disease: Design and EvolutionNon-Peptide BACE1 Inhibitors: Design and SynthesisPLASMEPSINS AND OTHER ASPARTIC PROTEASES AS DRUG TARGETSThe Plasmepsin Family as Antimalarial Drug TargetsDesign and Synthesis of Plasmepsin Inhibitors for Treatment of MalariaFungal aspartic proteases as possible therapeutic targets

Arun K. Ghosh studied chemistry at the University of Calcutta and the Indian Institute of Technology, Kanpur. He obtained his Ph.D. at the University of Pittsburgh and pursued post-doctoral research at Harvard University. He was a research fellow at Merck Research Laboratories prior to joining the University of Illinois, Chicago as an assistant Professor in 1994. In 2005, he moved to Purdue University where he is currently the Ian P. Rothwell Distinguished Professor of Chemistry and Medicinal Chemistry. His notable honors include, Arthur C. Cope Scholar Award, Robert Scarborough Medicinal Chemistry Award, American Association for the Advancement of Science, University of Illinois University Scholar, National Merit Scholar of India. He has published over 200 research papers and holds numerous patents. Professor Ghosh's research interests include diverse areas of organic, bioorganic and medicinal chemistry with particular emphasis on organic synthesis and protein-structure-based design of biomolecules.

"Overall, this book comprises an excellent themes and publications based on aspartic protease research, and I strongly recommend this book for novices, as well as experienced researchers in this area." (ChemMedChem, 2011)

"Overall, this book comprises an excellent themes and publications based on aspartic protease research, and I strongly recommend this book for novices, as well as experienced researchers in this area." (ChemMedChem, 2011)