Alzheimer's Disease

Protocol for the Systematic Fixation, Circuit-Based Sampling, and Qualitative and Quantitative Neuropathological Analysis of Human Brain Tissue.- Extraction and Purification of Single Nuclei from Frozen Human Brain Tissue.- Isolation of Human Microglia from Neuropathologically Diagnosed Cases in the Single-Cell Era.- Microglia in Human Postmortem Brain Samples: Quantitative Ultrastructural Analysis of Scanning Electron Microscopy Images.- Three-Dimensional Imaging of Fibrinogen and Neurovascular Alterations in Alzheimer's Disease.- Human Induced Pluripotent Stem Cell (hiPSC)-Derived Neurons and Glia for the Elucidation of Pathogenic Mechanisms in Alzheimer's Disease.- Modeling Alzheimer's Disease using Human Brain Organoids.- 3D Biohybrid StarPEG-Heparin Hydrogel Cultures for Modeling Human Neuronal Development and Alzheimer's Disease Pathology.- Computational Approaches to Assess Abnormal Metabolism in Alzheimer's Disease Using Transcriptomics.- FISHing for Chromosome Instability and Aneuploidy in the Alzheimer's Disease Brain.- Somatic CNV Detection by Single-Cell Whole-Genome Sequencing in Post-Mortem Human Brain.- Mass Spectrometry Analysis of the Human Brain Sphingolipidome.- Mass Spectrometry for the Advancement of Lipid Analysis in Alzheimer's Research.- The Use of Affinity Purification-Mass Spectrometry to identify Phosphorylates Tau Interactors in Alzheimer's Disease.- In Vitro Amplification of Pathogenic Tau Seeds from Neurodegenerative Disease Patient Brains.- Abeta and Tau Prions Causing Alzheimer's Disease.