Allergy Frontiers:Classification and Pathomechanisms

Classification and Pathomechanisms.- Basic Aspects of Allergy and Hypersensitivity Reactions.- Pathogen Recognition and New Insights into Innate Immunity.- New Nomenclature and Clinical Aspects of Allergic Diseases.- IgE and the High-Affinity Receptor, Fc?RI: The IgE-CD23 Interaction.- Superantigens and Allergic Disease.- Immune Complexes: Normal Physiology and Role in Disease.- What Is New About Eosinophil Activation in Asthma and Allergic Disease.- Mast Cell and Basophils: Interaction with IgE and Responses to Toll like Receptor Activators.- T Cells in Allergic Disease.- Role of NKT Cells in the Regulation of Ongoing Type 2 Immune Response.- CD8+ T Cells Play a Key Role in the Development of Allergic Lung Inflammation.- Neutrophils and Their Mediators in Asthma and Allergic Disease.- Dendritic Cells, Macrophages and Monocytes in Allergic Disease.- Function of Dendritic Cell Subsets in Allergic Disease.- Epithelial Cell-Mesenchymal Interaction, Epithelial-Leukocyte Interaction and Epithelial Immune-Response Genes in Allergic Disease.- Role of Epidermal Growth Factor Receptor Cascade in Airway Epithelial Regulation of Mucus Production.- Epithelial Cell Innate Responses to Rhinovirus Infection.- The Role of Platelets in Allergy.- Expression and Function of Siglec-8 in Human Eosinophils, Basophils, and Mast Cells.- Effects of Nitric Oxide on Mast Cells: Production, Functions, and Mechanisms of Action.- Histamine and Its Receptors.- Adenosine: Its Contribution to Our Understanding in Airway Inflammation.- Airway Smooth Muscle Dysfunction in Asthma.- Genetic Variation in Cytokines, Asthma, and Atopy: The Role of IL-4/IL-13 Pathway Polymorphisms.- Allergy and the Bone Marrow: Transmigration Pathways of Hemopoietic Progenitor Cells from the Bone Marrow.- HemopoieticMechanisms in Allergic Rhinitis and Asthma.- Allergy and the Nervous System.- Neuroanatomy of the Airways.- Biology of Neurotrophins, Neuropeptides, and Muscarinic Receptors in Asthma.- Neural Regulation of the

Prof. Stephen Holgate, MRC Clinical Professor of Immunopharmacology, Division of Respiratory Cell and Molecular Biology, University of Southhampton School of Medicine. Applying basic science to the clinical interface in allergy and asthma has been the guiding principle of Prof. Stephen Holgate's career. This has involved him in environmental and genetic epidemiology, physiology, cell and molecular biology of disease processes as they occur in humans. An AAAAI member since 1986 and Fellow from 1993, Professor Holgate has been active in the field of allergy and immunology both in the United Kingdom and overseas and in 2001 received the Academy's Honorary Fellow Award. He was President of the British Society of Allergy and Clinical Immunology (BSACI) from 1990-93 and the Robert Cook Memorial Lecturer in 1995 and 2000. He received the RCP London Graham Bull Prize for research and was elected an honorary member of the Association of Physicians in UK and Ireland following the delivery of the Sir William Osler Lecture in 2003. He has been an active contributor to the Collegium Internationale Allergologicum since 1990. Professor Holgate is a member of the Infection, Inflammation and Repair Division in the School of Medicine, University of Southampton at Southampton General Hospital, UK and since 1987 has held a Medical Research Council (MRC) Clinical Professorship. He received his undergraduate medical training at Charing Cross Hospital, London and specialised in respiratory medicine and allergy. He holds Fellowships from the Royal Colleges of Physicians, Pathologists, Institute of Biology and Academy of Medical Sciences. He is a member of the Royal Commission on Environmental Pollution and has been a censor of the Royal College of Physicians. He has served on a number of Government Committees including the Sub-committee for Efficacy and Adverse Drug Reactions of the CSM (SEAR), MRC Project Grant Committee, Systems Board, Cross Board Group and most recently Councils

From the reviews:

"Allergy Frontiers is a remarkable undertaking by 3 well-known experts in the field of allergy/immunology. ... This text brings the reader up to date on the basic science of allergic diseases. ... will serve as a catalyst for further research. ... helpful to clinicians, who are often challenged to understand why some patients respond to treatment and others do not. ... will serve as an invaluable resource for academicians, allergy/immunology training programs, and curious individuals who require more than a basic understanding of the subject." (Katherine Gundling, Journal of the American Medical Association, Vol. 302 (17), November, 2009)